Potential of Squid Ink Compounds as Insilicate FabH Protein In Silico

Tuberculosis (TB) is a disease with the second number of cases in Indonesia. The therapy process carried out by utilizing one waste materials, namely squid ink bags, which are predicted to have active compounds. In TB cycle, enzyme FabH catalyzed as mediator lipid synthesis. Inhibition became main target through role has potential bactery inhibitor. purpose this study was analyze an alternative inhibiting synthesis (FabH). silico approach used research. Bioactive compound 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (CID: 119405), cinnamic 444539), betaine 247) were downloaded from PubChem, and protein (PDB ID 2QO1) data bank database. (GDP). Docking HeX 8.0.0.0, visualization analysis using Discovery studio ver 21.1.1. Results analysis, we found compounds (DHICA), acid, contained molecularly FabH, interaction lead treatment TB. vitro vivo studies needed further before human studies.